Nathan Kuppermann, MD, MPH

Professor, Departments of Emergency Medicine and Pediatrics, University of California Davis School of Medicine

Dr. Kuppermann is Professor of Pediatric Emergency Medicine (PEM) and the Endowed Chair of the Department of Emergency Medicine at UC Davis. He is a leader in multicenter research in PEM, in the areas of infectious emergencies, diabetic ketoacidosis-related cerebral injury, the pediatric trauma patient. He has published his research in the New England Journal of Medicine, JAMA, and the Lancet. Dr. Kuppermann chaired the PEM Collaborative Research Committee of the AAP from 1996-2000, and then became the founding Chair of the Steering Committee of the Pediatric Emergency Care Applied Research Network (PECARN) in 2001. He has published more than 120 peer-reviewed scientific manuscripts, been awarded more than $20 million in federal grants and contracts, and been recognized nationally for his research and mentorship. In 2010, he was elected to the Institute of Medicine of the National Academies of Science.

Dr. Kuppermann's Lectures

Development and Application of Decision Rules

Highlighted Publications

1. Malley R, Huskins C, Kuppermann N. Multivariable Predictive Models for Adverse Outcome from Invasive Meningococcal Disease in Children. J Pediatr 1996;129:702-10.

2. Quayle K, Jaffe D, Kuppermann N, et al. Diagnostic Testing for Acute Head Injury in Children:When are Head CT and Skull Radiographs Indicated? Pediatrics 1997;99(5):e11.

3. Kuppermann N, Fleisher G, Jaffe D. Predictors of Occult Pneumococcal Bacteremia in Young Febrile Children. Ann Emerg Med, 1998;31:679-87.

4. Holmes JF, Sokolove PE, Land C, Kuppermann N. Identification of IntraabdominalInjuries in Children Hospitalized Following Blunt Torso Trauma. Acad Emerg Med 1999;6:799-806.

5. Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R,Kuppermann N. Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis. N Engl J Med 2001;344:264-269.

6. Holmes JF, Brant WE, Bond WF, Sokolove PE,Kuppermann N. Emergency Department Abdominal Ultrasound in the Evaluation of Hypotensive and Normotensive Children with Blunt Trauma. J Pediatr Surg 2001, 36:968-973.

7. Nguyen TP, Malley R, Inkelis S, Kuppermann N. Prediction of Adverse Outcome in Pediatric Meningococcal Disease Using Artificial Neural Networks or Logistic Regression. J Clin Epidemiol 2002;55:687-695.

8. Holmes JF, Sokolove PE, Brant WE, Kuppermann N. Clinical Predictors of Thoracic Injuries Among Children Sustaining Blunt Torso Trauma. Ann Emerg Med 2002;39:492-9.

9. Holmes JF, Sokolove PE, Palchak M, Vance C, Owings J,Kuppermann N. Identification of Children with Intra-Abdominal Injury after Blunt Trauma. Ann Emerg Med 2002;9:500-9.

10. Nigrovic LE, Kuppermann N, Malley R. Development and Validation of a Multivariable Predictive Model to Distinguish Bacterial From Aseptic Meningitis in Children in the Post-Haemophilus influenzae Era. Pediatrics 2002;110:712-719.

11. Marcin JP, Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R, Kuppermann N. Clinical and Therapeutic Factors Associated with Adverse Outcomes in Children with DKA-related Cerebral Edema. J Pediatr 2002;141:793-7.

12. The Pediatric Emergency Care Applied Research Network. The Pediatric Emergency Care Applied Research Network (PECARN): Rationale, Development, and First Steps. Acad Emerg Med 2003;10:661-668 and Pediatr Emerg Care 2003;19:185-193. (Kuppermann one of 4 lead authors)

13. Palchak M, Holmes J, Vance C, Gelber R, Schauer B, Harrison M, Willis-Shore J, Wooten-Gorges S, Derlet R, andKuppermann N. A Decision Rule for Identifying Children at Low Risk for Brain Injuries after Blunt Head Trauma. Ann Emerg Med 2003;42:492-506.

14. Palchak M, Holmes J, Vance C, Gelber R, Schauer B, Harrison M, Willis-Shore J, Wooten-Gorges S, Derlet R, andKuppermann N. Does an Isolated History of Loss of Consciousness or Amnesia Predict Brain Injuries in Children after Blunt Head Trauma? Pediatrics 2004;113:e507-e513.

15. Dayan PS, Vitale M, Ruzal-Shapiro C, Langsam DJ,Kuppermann N, Miller SZ. Derivation of Clinical Prediction Rules for Identifying Children with Fractures after Acute Twisting Injuries of the Ankle. Acad Emerg Med 2004;11:736-743.

16. Rose JS, Richards JR, Bair AE, Batistella F,Kuppermann N. The FAST is Positive, Now What? Derivation of Clinical Decision Rule to Determine the Need for Therapeutic Laparotomy Given a Positive Trauma Ultrasound. J Emerg Med 2005;29:15-21

17. Alpern A, Stanley R, Gorelick M, Donaldson A, Knight S, Teach S, Singh T, Mahajan P, Goepp J, Kuppermann N, Dean JM, Chamberlain J, for the Pediatric Emergency Care Applied Research Network. Epidemiology of a Pediatric Emergency Medicine Research Network: The PECARN Core Data Project. Pediatr Emerg Care 2006;22:689-99.

18. Nigrovic L., Kuppermann N, Macias C, et al for the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. Multicenter Validation of a Clinical Prediction Rule for Identifying Children with CSF Pleocytosis at Very Low Risk of Bacterial Meningitis. JAMA 2007;297:52-60.

19. Blackwell C, Gorelick M, Holmes J, Bandyopadhyay S,Kuppermann N. Pediatric Head Trauma: Changes in Evaluation and Management in Emergency Departments in the United States over Time. Ann Emerg Med 2007;49:320-324.

20. Miller SZ, Rincon H, Kuppermann N. Revisiting the EMS-C Research Agenda: A Review and Re-prioritization for the Pediatric Emergency Care Applied Research Network (PECARN). Acad Emerg Med 2008;15:377-383.

21. Awasthi S, Mao A, Gorges S, Wisner D, Kuppermann N, Holmes J. Is Hospital Admission and Observation Required after a Normal Abdominal CT Scan in Children with Blunt Abdominal Trauma? Acad Emerg Med 2008;15:895-9.

22. Kuppermann, N. Pediatric Head Trauma: the Evidence Regarding Indications for Emergent Neuroimaging. Pediatr Radiol 2008;38 Suppl 4:S670-4.

23. Palchak M, Holmes J, Kuppermann N. Clinical Judgment versus a Decision Rule for Identifying Children at Very Low Risk for Traumatic Brain Injury after Blunt Head Trauma. Pediatr Emerg Care 2009;25:61-5.

24. Holmes JF, Mao A, Awasthi S, McGahan J, Wisner D,Kuppermann N. Validation of a Prediction Rule for the Identification of Children with Intra-abdominal Injuries after Blunt Torso Trauma. Ann Emerg Med 2009;54:528-33.

25. Holmes JF, Wisner DH, McGahan JP, Mower WR,Kuppermann N. Clinical Prediction Rules for Identifying Adults at Very Low Risk of Intra-abdominal Injuries after Blunt Trauma. Ann Emerg Med 2009;54:575-84.

26. Kuppermann N, Holmes J, Dayan P, et al, and the Pediatric Emergency Care Applied Research Network (PECARN). Identification of Children at Very Low Risk of Clinically-Important Brain Injuries: a Prospective Cohort Study. Lancet 2009;374:1160-70.

27. Klassen TP, Acworth J, Beattie T et al (authorship in alphabetical order, includes Kuppermann N). Pediatric Emergency Research Networks (PERN): A Global Initiative in Pediatric Emergency Medicine. Pediatr Emerg Care 2010;26:541-3, and Eur J Emerg Med 2010;17:224-7.

28. Leonard J, Kuppermann N, Olsen C, et al for the Pediatric Emergency Care Applied Research Network (PECARN). Factors Associated with Cervical Spine Injury in Children Following Blunt Trauma. Ann Emerg Med 2011;58:145-55.

29. Nigrovic L, Schunk J, Forester A, et al and Kuppermann N for the Pediatric Emergency Care Applied Research Network (PECARN). The Effect of Observation on Head Computed Tomography (CT) for Children after Blunt Head Trauma. Pediatrics 2011;127:1067-73.

30. Maguire JL, Kulik D, Laupacis A, Kuppermann N, Uleryk E, Parkin P. Clinical Prediction Rules for Children – A Systematic Review. Pediatrics 2011:128;e666-77.

31. Natale J, Joseph J, Rogers A, Mahajan P, Cooper A, Wisner D, Miskin M, Hoyle J, Atabaki S, Dayan P, Holmes J,Kuppermann N, for PECARN. Cranial CT Use for Blunt Head Trauma In Children Is Associated with Race/Ethnicity. Arch Dis Adolesc Med 2012;166:732-7.

32. Horeczko T, Kuppermann N. To Scan or not to Scan: Pediatric Minor Head Trauma in Your Office, Clinic or Emergency Department. Contemp Pediatr 2012;29:40-7.

33. Holmes J, Lillis K, Monroe D, et al and Kuppermann N, and the Intra-abdominal Injury Study Group for the Pediatric Emergency Care Applied Research Network (PECARN). Identifying Children at Low Risk of Intra-abdominal Injuries Undergoing Acute Intervention. Annals of Emerg Med 2013, in press.