John MacKenzie, MD

Assistant Professor in Residence and Chief of Pediatric Radiology, UCSF

My work focuses on developing molecular imaging techniques for the detection and treatment monitoring of pediatric disease. My primary research focuses on how novel carbon-based imaging probes may depict molecular alterations in inflammatory disease, including inflammatory bowel and urinary disease. The development of sensitive, non-invasive imaging biomarkers for monitoring the treatment of patients with debilitating autoimmune diseases has the potential to transform the way we manage our patients. My long-term goal is to develop sensitive non-invasive imaging biomarkers to help guide the diagnosis and management of patients with autoimmune diseases and to bring new insights into understanding autoimmune disease through the lens of molecular imaging. 

For CT imaging of pediatric patients I study dose reduction strategies and how they affect image quality. This has led to several investigations in optimization of CT protocols and in testing new image reconstruction algorithms, such as model based iterative reconstruction, for improvements in image quality and dose optimization.

Dr. MacKenzie's Lectures

Ensuring the Most Accurate Imaging in Children

Highlighted Publications

  1. Seidl KJ, Mackenzie JD (co-first author), Wang D, Kantor AB, Kabat E and Herzenberg LA. Frequent occurrence of identical heavy and light chain Ig rearrangements. International Immunology. 1997. 9(5):689-702. PMID: 9184914
  2. Seidl KJ, Wilshire JA, Mackenzie JD, Kantor AB, Herzenberg LA and Herzenberg LA. Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Proceedings of the National Academy of Sciences USA. March 1999. 96(5): 2262-7. PMCID: PMC26771
  3. Mackenzie JD, Siddiqi F, Babb JS, Bagley LJ, Mannon LJ, Sinson GP, Grossman RI. Brain atrophy in mild and moderate closed head injury: a longitudinal quantitative analysis. American Journal of Neuroradiology. October 2002. 23:1509-1515. PMID: 12372740
  4. Shu KM, Mackenzie JD, Smith JB, Blinder EM, Bourgeois LM, Ledbetter S, Castronovo FP, Judy PF, FJ Rybicki. Lowering the thyroid dose in screening examinations of the cervical spine. Emergency Radiology. March 2006. 12(3): 133-6.
  5. Mackenzie JD, Nazario-Larrieu J, Cai T, Ledbetter SM, Duran-Mendicuti MA, Vargas TM, Judy PF, Rybicki FJ. Lower Dose Computed Tomography for the Detection of Acute Pulmonary Embolism. American Journal of Roentgenology, December 2007. 189(6):1371-9.
  6. Gu J, Nguyen L, Chaudari A, Mackenzie JD. Magnetic Resonance Molecular Imaging for Rheumatoid Arthritis. Topics in MRI. Top Magn Reson Imaging. 2011 Apr;22(2):61-9. PMID: 22648081
  7. Mackenzie JD, Yen Y, Mayer D, Tropp J, Hurd R, and Spielman DM. Detection of inflammatory arthritis using hyperpolarized 13C-pyurvate with magnetic resonance imaging and spectroscopy. Radiology. 2011. May;259(2):414-20. PMCID: PMC3079121
  8. Courtier J, Perito E, Rhee S, Heyman M, Mackenzie JD. Pediatric Hepatobiliary Magnetic Resonance Imaging with Gadoxetate Disodium. J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):454-62. PMID: 22193178
  9. Mackenzie JD, Hernandez A, Pena A, Gonzalez L, Ruppert K, Khrichenko D, Jawad AF, Wells L, Smith-Whitley K, Jaramillo D. Diffusion-Weighted Imaging in Early Avascular Necrosis - Measurement of the Apparent Diffusion Coefficient in the Hips of Sickle Cell Patients with Early Avascular Necrosis. Pediatric Radiology. 2012. Jun;42(6):706-13. PMID: 22200862
  10. Patel A, Soares B, Courtier J, and Mackenzie JD. Strategies to reduce radiation dose during pediatric musculoskeletal procedures. Pediatric Radiology. In press February 2013.